Is Oral Paclitaxel + Encequidar Effective for Breast Cancer?
Is Oral Paclitaxel + Encequidar Effective for Breast Cancer?
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Is Oral Paclitaxel + Encequidar Effective for Breast Cancer?
On July 20, 2022, Hope S. Rugo and colleagues from the University of California San Francisco published the results of the Phase III clinical trial on the efficacy and safety of oral Paclitaxel + Encequidar in patients with metastatic breast cancer in the medical journal Journal of Clinical Oncology.
This Phase III trial was an open-label study that randomized metastatic breast cancer patients (N = 402) in a 2:1 ratio into two groups: oral Paclitaxel (205mg/m2) + Encequidar (15mg, taken continuously for three days) group (21-day treatment cycles, N = 265) and intravenous Paclitaxel (175mg/m2) group (21-day treatment cycles, N = 137). The primary endpoint was imaging-based response rate, and secondary endpoints were progression-free survival and overall survival.
The trial results showed that the primary endpoint response rates were: oral Paclitaxel + Encequidar group 36% versus intravenous Paclitaxel group 23%.
The secondary endpoints showed that the median progression-free survival was: oral Paclitaxel + Encequidar group 8.4 months versus intravenous Paclitaxel group 7.4 months, and the median overall survival was: oral Paclitaxel + Encequidar group 22.7 months versus intravenous Paclitaxel group 16.5 months.
Regarding safety, the incidence of Grade 3-4 adverse events was: oral Paclitaxel + Encequidar group 55% versus intravenous Paclitaxel group 53%. The incidence of severe neuropathy was: oral Paclitaxel + Encequidar group 2% versus intravenous Paclitaxel group 15%. Hair loss incidence was: oral Paclitaxel + Encequidar group 49% versus intravenous Paclitaxel group 62%. Neutropenia was higher in the oral Paclitaxel + Encequidar group, particularly in patients experiencing nausea, vomiting, diarrhea, and hepatic dysfunction.
Based on the Phase III trial results, Hope S. Rugo and colleagues concluded that metastatic breast cancer patients receiving oral Paclitaxel + Encequidar showed improved progression-free survival and overall survival compared to the intravenous Paclitaxel group, with lower incidence of neuropathy-related adverse events.
Source: https://ascopubs.org/doi/full/10.1200/JCO.21.02953
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