(Prostate Cancer) Is Cabometyx Plus Tecentriq Effective? CONTACT-02 Phase 3 Trial Results
Medical Supporter — Information Notice
This article is a summary of international medical information and is not medical advice; it cannot replace the diagnosis or treatment plan of your attending physician. The medical technologies, drug information and clinical data presented here are compiled from public literature and official statements of major Japanese medical institutions; the applicability and outcome of any therapy vary with each patient and must be assessed individually by a qualified physician.
- August 28, 2023
- 1 min read
On August 22, 2023, Takeda Pharmaceutical announced that cabozantinib (Cabometyx) plus atezolizumab (Tecentriq) improved progression-free survival (PFS) in metastatic castration-resistant prostate cancer patients.
This announcement is based on interim analysis results from the CONTACT-02 international Phase 3 clinical trial. The CONTACT-02 trial enrolled patients with metastatic castration-resistant prostate cancer who had previously received hormone therapy as first-line treatment. Patients received Cabometyx plus Tecentriq as second-line therapy compared to hormone therapy. Primary endpoints were overall survival (OS) and PFS.
While OS showed an improvement trend in this interim analysis, the data are not yet mature. The study will continue to the next OS analysis.
Safety:
Adverse events for Cabometyx and Tecentriq individually were consistent with the known safety profiles of each agent as monotherapy. No new safety signals were identified with the combination.
Source: https://www.takeda.com/ja-jp/announcements/2023/Cabozantinib_Atezolizumab/
Prostate Cancer | Cabozantinib | Atezolizumab | CONTACT-02
-
Clinical Trial Medications
- (Lung Cancer) Phase II results for Topotecan and Topotecan + Berzosertib combination.
- (Lung Cancer) Efficacy of Enhertu in HER2-mutant non-small cell lung cancer (NSCLC).
- (Lung Cancer) Clinical outcomes of anti-B7-H3 antibody-drug conjugate DS-7300.
Medical Supporter was formerly certified as an international medical visa guarantor by Japan's Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry (B-066).
Considering medical care in Japan? Need information and support?
We help you organize the information needed for medical travel to Japan, liaise with Japanese medical institutions, and arrange a second-opinion consultation.The first consultation is free; an advisor will help you clarify the next steps.
Figure 1
Figure 2
Figure 3
Figure 4