Adjuvant Immunotherapy in High-Risk Renal Cell Carcinoma
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This article is a summary of international medical information and is not medical advice; it cannot replace the diagnosis or treatment plan of your attending physician. The medical technologies, drug information and clinical data presented here are compiled from public literature and official statements of Japanese medical institutions; the applicability and outcome of any therapy vary with each patient and must be assessed individually by a qualified physician.
CheckMate-914 Phase III Trial
- July 29, 2022
CheckMate-914 Phase III trial evaluated dual immune checkpoint blockade (nivolumab plus ipilimumab) as adjuvant therapy in patients with intermediate-to-high risk renal cell carcinoma after radical or partial nephrectomy.
Clinical Rationale
Adjuvant immunotherapy for high-risk RCC is being studied after surgical resection with the aim of reducing the risk of recurrence; trials evaluate whether immune activation against micrometastatic disease improves disease-free survival.
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