(NSCLC) East Asian Subgroup Analysis: Docetaxel Plus Ramucirumab (Cyramza) — REVEL Phase 3 Trial
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This article is a summary of international medical information and is not medical advice; it cannot replace the diagnosis or treatment plan of your attending physician. The medical technologies, drug information and clinical data presented here are compiled from public literature and official statements of major Japanese medical institutions; the applicability and outcome of any therapy vary with each patient and must be assessed individually by a qualified physician.
- March 22, 2016
- 1 min read
On February 22, 2016, Cancer Research and Treatment published a Phase 3 clinical trial subgroup analysis for non-small cell lung cancer (NSCLC) patients. This trial evaluated platinum-based chemotherapy combinations including docetaxel (taxotere), ramucirumab (Cyramza), and placebo. The original results were published in The Lancet in February 2014. This report presents the subgroup analysis for Asian patients.
The East Asian subgroup analysis (Taiwan and South Korea) enrolled 82 patients with Stage IV NSCLC. Docetaxel plus ramucirumab was evaluated for overall survival, adverse events, and response rate. Results showed a median overall survival of 10.3 months with combination therapy. Reducing the docetaxel dose to 60 mg/m² was associated with a lower frequency of adverse events. Based on these results, this treatment regimen was adopted in Japan the following year.
Detailed clinical trial data showing differences by dosage are available via the link below.
Source: East Asian Subgroup Analysis of a Randomized, Double-Blind, Phase 3 Study of Docetaxel and Ramucirumab Versus Docetaxel and Placebo in the Treatment of Stage IV Non-Small-Cell Lung Cancer Following Disease Progression After One Prior Platinum-Based Therapy (REVEL). Cancer Res Treat. 2016 Feb 22. doi:10.4143/crt.2015.401.
Lung Cancer | Ramucirumab | Docetaxel | REVEL
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