Ankle Arthritis: Autologous Stem Cell Regenerative Therapy
Medical Supporter — Information Notice
This article is a summary of international medical information and is not medical advice; it cannot replace the diagnosis or treatment plan of your attending physician. The medical technologies, drug information and clinical data presented here are compiled from public literature and official statements of major Japanese medical institutions; the applicability and outcome of any therapy vary with each patient and must be assessed individually by a qualified physician.
Regenerative Medicine Case Study
- July 3, 2019
Ankle joint arthritis, like hip and knee osteoarthritis, results from articular cartilage degeneration and inflammation. Regenerative medicine approaches using autologous stem cells offer potential therapeutic option.
Clinical Presentation
Patient presented with ankle pain during ambulation, with pain persisting even at rest. MRI imaging revealed severe inflammation of the talus, the bone central to ankle mobility.
Treatment Approach
Therapy: Autologous adipose tissue-derived mesenchymal stem cells (100 million cells) combined with platelet-rich plasma (PRP)
Clinical Outcomes
One-Month Follow-Up:
- Reduction in inflammatory response at treatment site
- Pain resolution at rest
- Persistent mild discomfort with weight-bearing activities
- Continued improvement expected with time
Mechanism of Action
Mesenchymal stem cells promote regeneration of damaged articular cartilage and modulate inflammatory response, supporting tissue healing and functional restoration.
Data Source
Iwata Clinic regenerative medicine case series
Medical Supporter was formerly certified as an international medical visa guarantor by Japan's Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry (B-066).
Considering medical care in Japan? Need information and support?
We help you organize the information needed for medical travel to Japan, liaise with Japanese medical institutions, and arrange a second-opinion consultation.The first consultation is free; an advisor will help you clarify the next steps.
Figure 1