(Ovarian Cancer) Is Rucaparib Effective as Maintenance Therapy?
Medical Supporter — Information Notice
This article is a summary of international medical information and is not medical advice; it cannot replace the diagnosis or treatment plan of your attending physician. The medical technologies, drug information and clinical data presented here are compiled from public literature and official statements of major Japanese medical institutions; the applicability and outcome of any therapy vary with each patient and must be assessed individually by a qualified physician.
On June 4, 2022, Bradley J. Monk and colleagues at Piper Cancer Care Network published results in the Journal of Clinical Oncology from the ATHENA–MONO/GOG-3020/ENGOT-ov45 (NCT03522246) Phase III clinical trial evaluating rucaparib as maintenance therapy in platinum-sensitive stage III/IV ovarian cancer patients after surgical resection.
The ATHENA–MONO/GOG-3020/ENGOT-ov45 Phase III trial was an international multicenter study that randomized platinum-sensitive stage III/IV ovarian cancer patients after surgical resection (N=538) in a 4:1 ratio to:
- Rucaparib group: Rucaparib 600 mg twice daily (N=427)
- Placebo group (N=111)
The primary endpoint was progression-free survival (PFS).
Results:
Among HRD patients (rucaparib group N=185, placebo group N=49):
- Median PFS: Rucaparib group 28.7 months vs. placebo group 11.3 months
Among non-HRD patients:
- Median PFS: Rucaparib group 12.1 months vs. placebo group 9.1 months
Among all patients:
- Median PFS: Rucaparib group 20.2 months vs. placebo group 9.2 months
Safety:
Grade ≥3 adverse events confirmed in the majority of patients were:
- Anemia: Rucaparib group 28.7% vs. placebo group 0%
- Neutropenia: Rucaparib group 14.6% vs. placebo group 0.9%
Based on the ATHENA–MONO/GOG-3020/ENGOT-ov45 trial results, Bradley J. Monk and colleagues concluded: Rucaparib maintenance therapy in platinum-sensitive stage III/IV ovarian cancer patients after surgical resection demonstrated good anti-tumor efficacy regardless of HRD status.
Source: https://ascopubs.org/doi/full/10.1200/JCO.22.01003
Medical Supporter was formerly certified as an international medical visa guarantor by Japan's Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry (B-066).
Considering medical care in Japan? Need information and support?
We help you organize the information needed for medical travel to Japan, liaise with Japanese medical institutions, and arrange a second-opinion consultation.The first consultation is free; an advisor will help you clarify the next steps.
Figure 1
Figure 2
Figure 3
Figure 4