ALK-Positive NSCLC: What Real-World Data Reported on First-Line Alectinib
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Real-World Evidence Analysis
- October 22, 2019
Data presented at the 2019 European Society for Medical Oncology Congress demonstrated real-world outcomes of alectinib versus crizotinib and ceritinib in untreated ALK-positive NSCLC patients (n=420).
Study Design
Patient Population: Untreated ALK-positive NSCLC (n=420)
Treatment Cohorts:
- Alectinib (n=98)
- Crizotinib (n=4)
- Ceritinib (n=318)
Endpoints: Progression-free survival, overall survival, treatment continuation
Key Results
Median Progression-Free Survival:
- Alectinib: Not reached
- Crizotinib: 5.06 months
- Ceritinib: 6.41 months
6-Month PFS Rates:
- Alectinib: 83%
- Crizotinib: 50%
- Ceritinib: 55%
12-Month PFS Rates:
- Alectinib: 68%
- Crizotinib: 25%
- Ceritinib: 36%
Overall Survival:
- Alectinib median OS: Not reached
- Longer survival metrics reported in this real-world study
Clinical Conclusions
Real-world analysis confirms alectinib efficacy in first-line ALK-positive NSCLC, with longer progression-free and overall survival reported compared with earlier-generation ALK inhibitors (literature data; for reference only).
Data Source
Roche ESMO 2019 presentation: Alecensa in first-line ALK-positive NSCLC
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