(Esophageal/Gastric Cancer) ASCO-GI 2018: Second-Line Pembrolizumab Plus Margetuximab Shows Efficacy in HER2-Positive Advanced Gastric and GEJ Adenocarcinoma
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- April 6, 2018
- Reading time: 1 minute
At the Gastrointestinal Cancers Symposium (ASCO-GI 2018) held in San Francisco, California, January 18–20, 2018, Dr. Daniel V.T. Catenacci of the University of Chicago Pritzker School of Medicine presented Phase 1b/2 clinical trial results (NCT02689284) evaluating pembrolizumab (Keytruda) plus the anti-HER2 antibody margetuximab as second-line therapy in patients with HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma previously treated with trastuzumab.
Trial Design
This trial evaluated second-line treatment in patients with HER2-positive gastric or GEJ adenocarcinoma who had received prior trastuzumab. The regimen consisted of a 21-day cycle with pembrolizumab 200 mg plus margetuximab at either 10 mg/kg or 15 mg/kg. The primary endpoint was response rate.
Two dosing cohorts were evaluated: 9 patients received 10 mg/kg, and the higher-dose 15 mg/kg cohort included 48 patients.
Efficacy Results
Of the 48 patients in the 15 mg/kg cohort, 38 were evaluable:
- Partial response (PR): 18.4% (N=7)
- Stable disease (SD): 28.9% (N=11)
Subgroup analysis of PR patients:
- North American patients (N=30): Response rate 8.3%
- Asian patients (N=18): Response rate 35.7%
By tumor location:
- Gastric cancer patients: 80%
- GEJ adenocarcinoma: 53%
Safety
Among all patients, one serious adverse event (AE) occurred. All other patients tolerated the combination of pembrolizumab plus margetuximab without that level of reaction, indicating a relatively high tolerability profile.
Conclusions
Based on these results, Dr. Daniel V.T. Catenacci concluded that second-line pembrolizumab plus margetuximab demonstrated meaningful antitumor activity and confirmed tolerability in HER2-positive advanced gastric and GEJ adenocarcinoma patients.
Source: Phase 1b/2 study of margetuximab (M) plus pembrolizumab (P) in advanced HER2+ gastroesophageal junction (GEJ) or gastric (G) adenocarcinoma (GEA). (ASCO-GI 2018, Abstract No. 140)
Tags: #GastricCancer #EsophagealCancer
- Clinical trial drug
Medical Supporter was formerly certified as an international medical visa guarantor by Japan's Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry (B-066).
هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
Figure 1
Figure 2
Figure 3
Figure 4