Abiraterone + Prednisone + LHRH Effective as Second-Line Treatment for Salivary Gland Cancer?

On October 1, 2021, Laura D. Locati and colleagues from Fondazione IRCCS Istituto Nazionale dei Tumori published the effectiveness and safety results of the Phase II clinical trial using the CYP17 inhibitor Abiraterone + Prednisone + LHRH as a second-line treatment for patients with androgen receptor-positive salivary gland cancer in the medical journal "Journal of Clinical Oncology."

In this Phase II clinical trial, patients with androgen receptor-positive salivary gland cancer (N=24) received Abiraterone (1g) once daily + Prednisone (10mg) + LHRH as second-line treatment. The primary endpoint was the objective response rate (ORR), and secondary endpoints included the disease control rate (DCR), safety, progression-free survival (PFS), and overall survival (OS).

The median age of patients in this trial was 65.8 years. The primary endpoint, objective response rate, was 21%, with 5 patients achieving a partial response. The secondary endpoints included a disease control rate of 62.5%, a duration of response (DOR) of 5.82 months, a median progression-free survival of 3.65 months, and a median overall survival of 22.47 months.

Regarding safety, the incidence of side effects was 92% (N=22). The incidence of Grade 3 side effects was 25% (N=6), which included fatigue (2 patients), hot flashes (1 patient), and supraventricular arrhythmia (1 patient).

Based on the results of the Phase II clinical trial, Laura D. Locati and others stated that the use of the CYP17 inhibitor Abiraterone + Prednisone + LHRH as second-line treatment in patients with androgen receptor-positive salivary gland cancer was well-tolerated with no significant safety concerns.

Source: https://ascopubs.org/doi/full/10.1200/JCO.21.00468

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