(Cervical Cancer) Is Keytruda Plus Platinum Chemotherapy ± Bevacizumab Effective? KEYNOTE-826 Phase 3 Results
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- November 15, 2021
- 2 min read
On November 11, 2021, Nicoletta Colombo and colleagues from the University of Milan-Bicocca published results in the New England Journal of Medicine from the KEYNOTE-826 Phase 3 clinical trial evaluating the efficacy and safety of pembrolizumab (Keytruda) plus platinum-based chemotherapy ± bevacizumab as first-line treatment in patients with persistent, metastatic, or recurrent cervical cancer.
This Phase 3 trial randomized patients 1:1 to pembrolizumab (200 mg every 3 weeks) plus platinum-based chemotherapy ± bevacizumab, or placebo plus platinum-based chemotherapy ± bevacizumab. The primary endpoints were progression-free survival (PFS) and overall survival (OS).
Results:
PD-L1 positive patients (CPS ≥1, N=548):
- Median PFS: Pembrolizumab 10.4 months vs. placebo 8.2 months
- 38% reduction in death risk with pembrolizumab
- 24-month OS rate: Pembrolizumab 53.0% vs. placebo 41.7%
All patients (N=617):
- Median PFS: Pembrolizumab 10.4 months vs. placebo 8.2 months
- 35% reduction in death risk with pembrolizumab
- 24-month OS rate: Pembrolizumab 50.4% vs. placebo 40.4%
PD-L1 positive patients (CPS ≥10, N=317):
- Median PFS: Pembrolizumab 10.4 months vs. placebo 8.1 months
- 42% reduction in death risk with pembrolizumab
- 24-month OS rate: Pembrolizumab 54.4% vs. placebo 44.6%
Safety:
Most common Grade 3–5 adverse events: anemia (pembrolizumab 30.3% vs. placebo 26.9%), neutropenia (pembrolizumab 12.4% vs. placebo 9.7%).
Conclusion: Based on the KEYNOTE-826 trial results, Nicoletta Colombo and colleagues concluded that pembrolizumab plus platinum-based chemotherapy ± bevacizumab as first-line treatment significantly improved PFS and OS in patients with persistent, metastatic, or recurrent cervical cancer.
Source: https://pubmed.ncbi.nlm.nih.gov/34534429/
Cervical Cancer | Immunotherapy | Keytruda | KEYNOTE-826
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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