(Gestational Trophoblastic Tumor) Is Anti-PD-1 Camrelizumab Plus Apatinib Effective?
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- November 2, 2021
- 1 min read
On October 5, 2021, Dr. Hongyan Cheng and colleagues from Peking Union Medical College Hospital published results in The Lancet from a Phase 2 clinical trial evaluating the efficacy and safety of the anti-PD-1 antibody camrelizumab combined with apatinib in patients with high-risk, chemotherapy-resistant, recurrent gestational trophoblastic tumors (GTT).
This Phase 2 trial was a single-arm, open-label study with a 4-week treatment cycle. Patients with high-risk, chemotherapy-resistant, recurrent GTT received camrelizumab (200 mg on days 1 and 15) plus apatinib (250 mg once daily) until disease progression or unacceptable toxicity. The primary endpoint was objective response rate (ORR).
Results at median follow-up of 18.5 months:
- Objective response rate (ORR): 55%
- Complete response (CR): 50%
Safety:
Grade 3 or higher adverse events observed in most patients included hypertension (25%, N=5), skin abnormalities (20%, N=4), and neutropenia (10%, N=2). No higher-grade adverse events were confirmed.
Conclusion: Based on the Phase 2 trial results, Dr. Cheng and colleagues concluded that camrelizumab plus apatinib demonstrated meaningful anti-tumor activity with acceptable tolerability in high-risk, chemotherapy-resistant, recurrent GTT patients, and may represent a new treatment option for this patient population.
Source: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00460-5/fulltext
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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