Is Hormone Therapy + Everolimus Effective for Breast Cancer?
Is Hormone Therapy + Everolimus Effective for Breast Cancer?
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
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Formerly certified by Japan's Ministry of Foreign Affairs Medical Visa Guarantee Agency B-66 Travel Services Arrangement Business License No. 35, Fukuoka Prefecture, Japan Japanese Medical Equipment Sales and Rental Business Management
Is Hormone Therapy + Everolimus Effective for Breast Cancer?
On May 23, 2022, Thomas Bachelot and colleagues from Centre Leon Berard published the results of a Phase III clinical trial (NCT01805271) on the efficacy and safety of hormone therapy + Everolimus as adjuvant therapy in high-risk, hormone receptor-positive, HER2-negative primary breast cancer patients in the Journal of Clinical Oncology.
This Phase III clinical trial randomized high-risk, hormone receptor-positive, HER2-negative primary breast cancer patients (N = 1278) into two groups: hormone therapy + Everolimus (continued for 2 years) and hormone therapy + placebo (continued for 2 years). The primary endpoint was progression-free survival.
The trial results showed that for the primary endpoint, the 3-year progression-free survival rate was: hormone therapy + Everolimus group 88% versus hormone therapy + placebo group 89%, showing no significant difference between the two groups. Regarding safety, the incidence of Grade 3 or higher adverse events was: hormone therapy + Everolimus group 29.9% versus hormone therapy + placebo group 15.9%. The rate of treatment discontinuation early in the trial was: hormone therapy + Everolimus group 53.4% versus hormone therapy + placebo group 22.3%.
Based on the Phase III clinical trial results, Thomas Bachelot and colleagues concluded that high-risk, hormone receptor-positive, HER2-negative primary breast cancer patients receiving hormone therapy + Everolimus as adjuvant therapy showed no significant improvement in progression-free survival, and approximately half of patients discontinued Everolimus treatment. They do not recommend Everolimus as adjuvant therapy.
Source: https://ascopubs.org/doi/abs/10.1200/JCO.21.02179
https://ascopubs.org/doi/abs/10.1200/JCO.21.02179
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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