(Liver Cancer) Opdivo + Yervoy After Sorafenib Resistance?
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
At ASCO 2019 (American Society of Clinical Oncology Annual Meeting) held in Chicago from May 31 to June 4, 2019, results were presented from the CheckMate 040 Phase I/II clinical trial evaluating the efficacy and safety of combined anti-PD-1 antibody Opdivo (nivolumab) + anti-CTLA-4 antibody Yervoy (ipilimumab) in hepatocellular carcinoma (HCC) patients who developed resistance to or could not tolerate sorafenib (Nexavar).
The CheckMate 040 trial randomized HCC patients with sorafenib resistance or intolerance in a 1:1:1 ratio across three groups. Primary endpoints: safety, tolerability, ORR, and duration of response (DoR). Secondary endpoints: disease control rate (DCR), time to tumor progression (TTP), PFS, OS, and duration of response.
- Arm A: Opdivo 1 mg/kg + Yervoy 3 mg/kg every 3 weeks for 4 cycles, then Opdivo 240 mg every 2 weeks
- Arm B: Opdivo 3 mg/kg + Yervoy 1 mg/kg every 3 weeks for 4 cycles, then Opdivo 240 mg every 2 weeks
- Arm C: Opdivo 3 mg/kg every 2 weeks + Yervoy 1 mg/kg every 6 weeks
Results:
Primary endpoint ORR: Arm A 32% (CR 8%) / Arm B 31% (CR 6%) / Arm C 31% (CR 0%)
Duration of response: Arm A 17.5 months / Arm B 22.2 months / Arm C 16.6 months
Secondary endpoints:
- DCR: Arm A 54% / Arm B 43% / Arm C 49%
- TTP: Arm A 2.0 months / Arm B 2.6 months / Arm C 2.7 months
- Median OS: Arm A 22.8 months / Arm B 12.5 months / Arm C 12.7 months
Safety:
Overall adverse event rates: Arm A 94% / Arm B 71% / Arm C 79%. Rash, hepatitis, and adrenal insufficiency were confirmed as common adverse events across all groups.
Based on the CheckMate 040 results, Thomas Yau concluded: In HCC patients with sorafenib resistance or intolerance, combined anti-PD-1 antibody Opdivo + anti-CTLA-4 antibody Yervoy demonstrated high objective response rates.
Source: Nivolumab (NIVO) + ipilimumab (IPI) combination therapy in patients (pts) with advanced hepatocellular carcinoma (aHCC): Results from CheckMate 040. (2019 ASCO Annual Meeting, Abstract No: 4012)
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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