(Solid Tumors) Is Opdivo Effective?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
On November 25, 2019, Nilofer S. Azad published in the Journal of Clinical Oncology the "Efficacy and Safety Results of Single-Agent Opdivo (nivolumab) Anti-PD-1 Antibody Therapy in Patients with dMMR Solid Tumors Other Than Colorectal Cancer in the NCI-MATCH (EAY131) Phase II Clinical Trial."
In this Phase II clinical trial, patients with dMMR solid tumors other than colorectal cancer received single-agent Opdivo therapy (3mg/kg every 2 weeks for 4 cycles, then 480mg every 4 weeks). The primary endpoint was objective response rate.
This trial was initiated because clinical data on single-agent Opdivo therapy in patients with dMMR solid tumors other than colorectal cancer was limited, and the trial aimed to confirm its utility.
Background of enrolled patients (N=42):
Solid tumor types:
- Endometrial cancer: 13 patients
- Prostate cancer: 5 patients
- Uterine sarcoma: 4 patients
- Esophageal/gastroesophageal junction: 3 patients
- Cholangiocarcinoma: 3 patients
- Ductal carcinoma: 3 patients
- Pancreatic neuroendocrine tumor: 1 patient
Sex: Male 67%, Female 33%
Median age: 60 years (range 44-85)
Race: White 83%, Black 10%, Asian 5%, Hispanic 5%
Prior treatment history: 1 prior treatment 24%, 2 prior treatments 19%, 3 prior treatments 10%, 4 or more prior treatments 45%
The trial results were as follows: the primary endpoint objective response rate was 36%, with complete response at 7% (N=3) and partial response at 29% (N=13), and stable disease at 21% (N=9).
The 6-month, 12-month, and 18-month progression-free survival rates were 51.3%, 46.2%, and 31.4%, respectively. The median overall survival was 17.3 months.
Regarding safety, the most commonly observed grade 1-3 adverse events were fatigue (40%), anemia (33%), skin disorders (17%), and hypoproteinemia (17%). No grade 5 adverse events were observed.
Based on the NCI-MATCH (EAY131) trial results, Nilofer S. Azad concluded: "Single-agent Opdivo anti-PD-1 antibody therapy showed significant antitumor effects in patients with dMMR solid tumors other than colorectal cancer, without serious adverse events."
Source: Nivolumab Is Effective in Mismatch Repair–Deficient Noncolorectal Cancers: Results From Arm Z1D—A Subprotocol of the NCI-MATCH (EAY131) Study (J Clin Oncol. 2019 Nov 25:JCO1900818. doi: 10.1200/JCO.19.00818.)
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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