Is Retevmo Effective for Lung Cancer?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
On September 19, 2022, Alexander Drilon and colleagues from Memorial Sloan Kettering Cancer Center and Weill Cornell Medical Center published the results of the Phase 1/2 LIBRETTO-001 trial in the "Journal of Clinical Oncology." The study evaluated the efficacy and safety of Retevmo (selpercatinib) in patients with RET fusion-positive non-small cell lung cancer (NSCLC).
LIBRETTO-001 is a single-arm, open-label Phase 1/2 trial. A total of 316 patients with RET fusion-positive NSCLC were treated with Retevmo. The primary endpoint was objective response rate (ORR), and secondary endpoints included duration of response (DOR), progression-free survival (PFS), overall survival (OS), and safety. The study included 69 treatment-naive patients and 247 patients who had previously received platinum-based chemotherapy.
For treatment-naive patients, the primary endpoint ORR was 84%, with a 6% complete response (CR) rate. Secondary endpoints included a median DOR of 20.2 months and a median PFS of 22.0 months.
For patients previously treated with platinum-based chemotherapy, the primary endpoint ORR was 61%, with a 7% CR rate. Secondary endpoints included a median DOR of 28.6 months and a median PFS of 24.9 months.
In patients with central nervous system (CNS) metastases (N=26), the intracranial ORR was 85%, with a 27% CR rate.
Regarding safety, the adverse event profile was consistent with previously reported data, and no new safety signals were identified.
Based on the LIBRETTO-001 results, Alexander Drilon stated that Retevmo demonstrates significant anti-tumor activity in patients with RET fusion-positive NSCLC, regardless of prior treatment, including those with intracranial metastases.
Source: https://ascopubs.org/doi/full/10.1200/JCO.22.00393
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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