(Colorectal Cancer) Is Murlentamab + Trifluridine (Lonsurf) Combination Effective?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
At the ESMO World Congress on Gastrointestinal Cancer held in Barcelona, Spain from July 3–6, 2019, Eric Van Cutsem presented the efficacy and safety results from a Phase II clinical trial evaluating anti-AMHR-II monoclonal antibody Murlentamab (GM102) monotherapy and Murlentamab + trifluridine (Lonsurf) combination therapy in patients with locally advanced or metastatic colorectal cancer.
The Phase II trial enrolled patients with locally advanced or metastatic colorectal cancer and administered either Murlentamab (GM102) 7 mg/kg monotherapy weekly (N=21) or Murlentamab (GM102) 7 mg/kg + trifluridine combination (N=18). The primary endpoint was objective response rate (ORR); secondary endpoints were progression-free survival (PFS) and safety.
Patient Characteristics:
- Median age: 60 years; male: 61.5%
- Primary site: rectum 33.3%, colon 66.7%; right-sided 50%, left-sided 50%
- KRAS mutation: 64.1%; median prior treatment lines: 3
- AMHR-II positive rate: 85.3%
Results:
Primary endpoint ORR:
- Monotherapy group (N=14): No confirmed responses. Disease stabilization rate at Month 2: 21.4%; Month 4: 7.1%
- Combination group (N=15): No confirmed responses. Disease stabilization rate at Month 2: 53.3%; Month 4: 40.0%; Month 6: 30.8%
In the combination group, median treatment duration was 6.0 months for patients with ≥20% AMHR-II-positive tumor cells, versus 2.4 months for those with <20%.
Safety:
Adverse events were confirmed in 10 patients in the combination group only. Most adverse events were loss of appetite, vomiting, nausea, constipation, and fatigue.
Based on the Phase II trial results, Eric Van Cutsem concluded: In patients with locally advanced or metastatic colorectal cancer with high AMHR-II expression, Murlentamab + trifluridine combination therapy showed favorable progression-free survival.
Source: Phase 2 study results of murlentamab, a monoclonal antibody targeting the Anti-Mullerian-Hormone-Receptor II (AMHRII), acting through Tumor-Associated Macrophage engagement in advanced/metastatic colorectal cancers (WCGC 2019 Abstract #LBA-004)
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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