(Gastric Cancer) Is Pembrolizumab Plus Lenvatinib Effective?
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- July 20, 2020
- Reading time: 2 minutes
On June 23, 2020, Akihito Kawazoe published in the medical journal The Lancet the EPOC1706 Phase 2 trial results verifying the efficacy and safety of first-line pembrolizumab (Keytruda) plus lenvatinib — a multikinase tyrosine kinase inhibitor — in patients with advanced gastric cancer.
Trial Design
This Phase 2 trial enrolled 29 patients with advanced gastric cancer and administered pembrolizumab (200 mg, 3-week cycles) plus lenvatinib (20 mg once daily) as first-line treatment. The primary endpoint was objective response rate (ORR). Secondary endpoints included adverse event rate, progression-free survival (PFS), and overall survival (OS).
Background: Anti-PD-1 antibody pembrolizumab alone achieves approximately 15% antitumor activity in advanced gastric cancer. Preclinical results confirmed that combining a multikinase tyrosine kinase inhibitor lenvatinib with an anti-PD-1 antibody enhanced antitumor efficacy, providing the rationale for this trial.
Efficacy Results
At a median follow-up of 12.6 months, the primary endpoint ORR was 69%.
Safety Profile
Grade 3 adverse events confirmed in most patients:
- Hypertension: 38%
- Proteinuria: 17%
- Thrombocytopenia: 7%
No patient deaths due to adverse events were confirmed.
Conclusions
Based on the Phase 2 trial results, Akihito Kawazoe concluded that first-line pembrolizumab plus lenvatinib in patients with advanced gastric cancer demonstrated sufficient antitumor activity with acceptable tolerability.
Source: Lenvatinib plus pembrolizumab in patients with advanced gastric cancer in the first-line or second-line setting (EPOC1706): an open-label, single-arm, phase 2 trial. Lancet Oncol. 2020 Jun 23.
- Clinical trial drug
- Immunotherapy
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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