(Colorectal Cancer) Is Adagrasib ± Cetuximab Effective? KRYSTAL-1 Phase 1/2 Trial Results
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- February 1, 2023
- 1 min read
On December 21, 2022, Rona Yaeger and colleagues from Memorial Sloan Kettering Cancer Center published results in the New England Journal of Medicine from the KRYSTAL-1 Phase 1/2 clinical trial evaluating the efficacy and safety of adagrasib ± cetuximab in previously treated KRAS G12C mutation-positive metastatic colorectal cancer patients.
Trial Design:
The KRYSTAL-1 trial was an open-label, non-randomized study enrolling previously treated KRAS G12C mutation-positive metastatic colorectal cancer patients (N=76), divided into:
- Adagrasib monotherapy group: 600 mg twice daily (N=44)
- Adagrasib 600 mg twice daily + cetuximab 250 mg/m² weekly or 500 mg/m² biweekly (N=32)
Primary endpoints were objective response rate (ORR) and safety.
Results at median follow-up of 20.1 months (monotherapy) and 17.5 months (combination):
| Endpoint | Adagrasib alone | Adagrasib + Cetuximab |
|---|---|---|
| ORR | 19% | 46% |
| Median duration of response | 4.3 months | 7.6 months |
| Median PFS | 5.6 months | 6.9 months |
Safety:
Grade 3–4 adverse events: Adagrasib alone 34% vs. adagrasib + cetuximab 16%.
Conclusion: Based on the KRYSTAL-1 trial results, Rona Yaeger and colleagues concluded that adagrasib ± cetuximab demonstrated favorable anti-tumor activity in previously treated KRAS G12C-mutant metastatic colorectal cancer patients, with the combination showing a duration of response exceeding 6 months.
Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2212419
Colorectal Cancer | KRAS G12C | Adagrasib | Cetuximab
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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