(Prostate Cancer) Is Niraparib Effective?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
On February 4, 2022, Dr. Matthew R. Smith and colleagues from Massachusetts General Hospital Cancer Center published results in The Lancet Oncology from the Phase 2 clinical trial (NCT02854436) evaluating the efficacy and safety of oral PARP inhibitor Niraparib monotherapy in previously treated, DNA repair gene-deficient, castration-resistant metastatic prostate cancer patients.
This Phase 2 trial was a multi-center, open-label study administering Niraparib monotherapy to previously treated patients with DNA repair gene defects and castration-resistant metastatic prostate cancer (N=289) until disease progression or unacceptable toxicity. The primary endpoint was objective response rate (ORR).
Of the 289 enrolled patients, 63% (N=182) had received three or more prior lines of therapy. Among the 223 evaluable patients, 142 were BRCA-mutation positive and 81 were BRCA-mutation negative.
Results at median follow-up of 10 months:
In BRCA-mutation positive patients (N=76): Primary endpoint ORR was 34.2%.
Safety:
Most common treatment-related adverse events: nausea (58%, N=169/289), anemia (54%, N=156), vomiting (38%, N=111). Grade 3 or higher adverse events: anemia (33%, N=95), thrombocytopenia (16%, N=47), neutropenia (10%, N=28). Serious adverse events occurred in 46% (N=134/289), including thrombocytopenia (6%, N=17) and anemia (4%, N=13).
Conclusion: Based on the Phase 2 trial results, Dr. Smith and colleagues concluded that Niraparib monotherapy demonstrated meaningful anti-tumor activity with acceptable tolerability in previously treated, DNA repair gene-deficient, castration-resistant metastatic prostate cancer patients.
Source: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00757-9/fulltext
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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