(Breast Cancer) Is Patritumab Deruxtecan Effective?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
From June 3–7, 2022, Dr. Ian E. Krop and colleagues from the Dana-Farber Cancer Institute presented results at the American Society of Clinical Oncology (ASCO) annual meeting in Chicago on the efficacy and safety of patritumab deruxtecan in the U31402-A-J101 Phase 1/2 clinical trial in previously treated HER3-positive metastatic breast cancer patients.
The U31402-A-J101 Phase 1/2 trial was an open-label, multi-center study. An initial dose-escalation phase enrolled 66 patients with HER3-positive metastatic breast cancer and evaluated the safety, tolerability, and maximum tolerated dose of patritumab deruxtecan on a 3-week cycle. Subsequent dose-expansion cohorts enrolled different patient subtypes at the following doses:
- HER3 high-expressing group: 4.8 mg/kg (N=66) and 6.4 mg/kg (N=31)
- HER3 low-expressing group: 6.4 mg/kg (N=21)
- HR+/HER2−, triple-negative, and HER3 high-expressing: 6.4 mg/kg (N=31)
Patient characteristics: median age 57 years (range: 30–83), ECOG PS 0 in 72.5% (N=132) and ECOG PS 1 in 27.5% (N=50), median prior therapies: 5 (range: 1–13).
At a median follow-up of 31.9 months, objective response rates (ORR) were:
- HR+/HER2−, HER3 high+low expressing: 30.1% (N=113)
- Triple-negative breast cancer, HER3 high-expressing: 22.6% (N=53)
- HER2-positive, HER3 high-expressing: 42.9% (N=14)
Median duration of response was:
- HR+/HER2−, HER3 high+low expressing: 7.2 months
- Triple-negative, HER3 high-expressing: 5.9 months
- HER2-positive, HER3 high-expressing: 8.3 months
Safety: Grade 3 or higher adverse events occurred in 71.4% (N=130). Adverse events occurring in ≥15% of patients included: neutropenia (39.6%), thrombocytopenia (30.8%), anemia (18.7%), and leukopenia (18.1%). Treatment-related interstitial lung disease was observed in 6.6% (N=12), including one Grade 5 event.
Conclusion: Based on U31402-A-J101 trial results, Dr. Krop and colleagues concluded that patritumab deruxtecan demonstrated meaningful anti-tumor activity with manageable tolerability in previously treated HER3-positive metastatic breast cancer patients across triple-negative, HR+/HER2−, and HER2-positive subtypes.
Source: https://meetings.asco.org/abstracts-presentations/206936
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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