Belzutifan and Cabozantinib in Renal Cell Carcinoma
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- April 17, 2023
- Reading time: 1 minute
On March 31, 2023, Dr. Toni K. Choueiri and colleagues from the Dana-Farber Cancer Institute published the efficacy and safety results of a Phase 2 clinical trial (NCT03634540) in The Lancet Oncology. The study evaluated the combination of Belzutifan and Cabozantinib in patients with locally advanced or metastatic clear cell renal cell carcinoma (ccRCC) who had previously received immunotherapy.
Study Design: This was an open-label, single-arm Phase 2 clinical trial enrolling 52 patients with ccRCC. Participants were treated with Belzutifan (120 mg once daily) and Cabozantinib (60 mg once daily) until disease progression or unacceptable toxicity occurred. The primary endpoint was the objective response rate (ORR).
Clinical Outcomes: At a median follow-up of 24.6 months, the results were as follows:
- Objective Response Rate (ORR): 30.8%.
- Complete Response (CR): 2% (N=1).
- Partial Response (PR): 29% (N=15).
Safety and Tolerability: The most common Grade 3–4 adverse event was hypertension, occurring in 27% of patients. The incidence of serious adverse events (SAEs) was 29%.
Conclusion: Based on the results of this Phase 2 trial, Dr. Toni K. Choueiri and the research team concluded that the combination of Belzutifan and Cabozantinib demonstrated promising anti-tumor activity in patients with advanced clear cell renal cell carcinoma who had previously undergone immunotherapy.
Source: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(23)00097-9/fulltext
- Clinical Trial Medications
- (Lung Cancer) Phase II results for Topotecan and Topotecan + Berzosertib combination.
- (Lung Cancer) Efficacy of Enhertu in HER2-mutant non-small cell lung cancer (NSCLC).
- (Lung Cancer) Clinical outcomes of anti-B7-H3 antibody-drug conjugate DS-7300.
Medical Supporter was formerly certified as an international medical visa guarantor by Japan's Ministry of Foreign Affairs and the Ministry of Economy, Trade and Industry (B-066).
هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
Figure 1
Figure 2
Figure 3
Figure 4