(Colorectal Cancer) Pertuzumab Plus Trastuzumab — Objective Response Rate 32%
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
HER2-Targeted Therapy: Pertuzumab Plus Trastuzumab in HER2-Amplified Metastatic Colorectal Cancer
- May 31, 2019
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Objective Response Rate of 32% with Pertuzumab Plus Trastuzumab in HER2-Amplified Metastatic Colorectal Cancer
On March 8, 2019, a Phase 2 clinical trial evaluating the efficacy and safety of the anti-HER2 monoclonal antibody combination of pertuzumab (Perjeta) plus trastuzumab (Herceptin) in patients with HER2-amplified metastatic colorectal cancer who had received multiple prior lines of therapy was published in the medical journal The Lancet Oncology.
Trial Design
This Phase 2 trial administered treatment to patients every 3 weeks, with the treating physician evaluating objective response rate.
Background: Given established evidence of efficacy of anti-HER2 antibodies pertuzumab and trastuzumab in HER2-positive breast cancer, gastric cancer, and other solid tumors, this trial was conducted based on the hypothesis that these agents might also benefit patients with HER2-amplified metastatic colorectal cancer.
Results
Efficacy: Among patients with HER2 amplification, the objective response rate (ORR) was 32%.
Safety: Most common adverse events: diarrhea, fatigue, and nausea. Less common adverse events: hypokalemia and abdominal pain. No treatment-related deaths occurred.
Based on the trial results, heavily pretreated patients with HER2-amplified metastatic colorectal cancer demonstrated acceptable tolerability and meaningful antitumor activity with this combination therapy.
Source: Pertuzumab plus trastuzumab for HER2-amplified metastatic colorectal cancer (MyPathway): an updated report from a multicentre, open-label, phase 2a, multiple basket study. Lancet Oncology, Published: March 08, 2019.
Tags: #ColorectalCancer
- Clinical trial drug
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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