(Colorectal Cancer) Is Panitumumab + Lonsurf Effective?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- May 29, 2023
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On May 18, 2023, Stefania Napolitano et al. from Università degli Studi della Campania "Luigi Vanvitelli" published in JAMA Oncology the efficacy and safety results of panitumumab + Lonsurf (trifluridine/tipiracil) as third-line treatment in refractory RAS wild-type recurrent colorectal cancer patients in the VELO Phase 2 clinical trial.
The VELO Phase 2 clinical trial was an open-label, randomized trial that randomized refractory RAS wild-type recurrent colorectal cancer patients 1:1 into the panitumumab + Lonsurf group and the Lonsurf monotherapy group. The primary endpoint was progression-free survival.
Patient characteristics for the 62 participants enrolled: median age was 65 years (range 39–81) for the panitumumab + Lonsurf group and (range 32–82) for the Lonsurf group; male percentage was 61.3% (N=19) for the panitumumab + Lonsurf group and 54.8% (N=17) for the Lonsurf group.
Trial results: the primary endpoint median progression-free survival was: panitumumab + Lonsurf group 4.0 months / Lonsurf group 2.5 months. The 6-month progression-free survival rate was: panitumumab + Lonsurf group 38.5% / Lonsurf group 13.0%. The 12-month progression-free survival rate was: panitumumab + Lonsurf group 15.4% / Lonsurf group 0%.
Based on the VELO trial results, Stefania Napolitano et al. stated: In refractory RAS wild-type recurrent colorectal cancer patients, panitumumab + Lonsurf as third-line treatment improved progression-free survival compared to Lonsurf monotherapy.
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Source: https://jamanetwork.com/journals/jamaoncology/fullarticle/2805081
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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