(Melanoma) Is Opdivo + Yervoy Effective for Brain Metastases? — CheckMate 204 3-Year Follow-Up
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هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
On November 11, 2021, Hussein A. Tawbi and colleagues from the University of Texas MD Anderson Cancer Center published 3-year follow-up efficacy and safety results of the CheckMate 204 Phase II clinical trial in The Lancet Oncology, evaluating nivolumab (Opdivo, anti-PD-1) plus ipilimumab (Yervoy, anti-CTLA-4) in patients with malignant melanoma with brain metastases.
The CheckMate 204 Phase II trial was a multicenter, open-label study. Patients with malignant melanoma with brain metastases (N=119) received nivolumab (1 mg/kg) plus ipilimumab (3 mg/kg) every 3 weeks for 4 cycles, followed by nivolumab monotherapy (3 mg/kg) every 2 weeks for up to 2 years, or until disease progression or unacceptable toxicity. The primary endpoint was intracranial clinical benefit rate; secondary endpoints were intracranial progression-free survival and overall survival. Patients were stratified into cohort A (asymptomatic, N=101) and cohort B (symptomatic, N=18).
Results:
Intracranial clinical benefit rate (primary endpoint): cohort A 57.4% (N=58) / cohort B 16.7% (N=3). Complete response: cohort A 33% (N=33) / cohort B 17% (N=3).
Cohort A secondary endpoints at 36 months: intracranial PFS rate 54.1%; OS rate 36.6%.
Safety:
Most common Grade 3–4 adverse events: cohort A — AST/ALT elevation 15% (N=15); cohort B — none. Serious adverse events in cohort A included colitis, diarrhea, hypophysitis, and ALT elevation; cohort B had none.
Based on the 3-year follow-up results of the CheckMate 204 trial, Hussein A. Tawbi and colleagues concluded that nivolumab plus ipilimumab demonstrated durable antitumor activity, improving intracranial progression-free survival and overall survival in patients with malignant melanoma with brain metastases.
Source: https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(21)00545-3/fulltext
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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