(Prostate Cancer) Is Talazoparib + Enzalutamide Effective?
Medical Supporter — إشعار معلوماتي
هذه المقالة ملخص لمعلومات طبية دولية وليست نصيحة طبية، ولا يمكن أن تحل محل تشخيص طبيبك المعالج أو خطة العلاج. المعلومات المعروضة مجمّعة من منشورات عامة وبيانات رسمية لكبرى المؤسسات الطبية اليابانية؛ وتختلف ملاءمة ونتائج أي علاج من مريض لآخر ويجب أن يقيّمها طبيب مؤهل لكل حالة على حدة.
- February 27, 2023
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From February 16–18, 2023, Neeraj Agarwal of Huntsman Cancer Institute and colleagues presented at ASCO GU 2023 in San Francisco, California, the efficacy and safety results of Talazoparib + Enzalutamide as first-line treatment in metastatic castration-resistant prostate cancer patients in the TALAPRO-2 Phase 3 clinical trial.
The TALAPRO-2 Phase 3 clinical trial was a randomized, double-blind trial that randomized metastatic castration-resistant prostate cancer patients (N=805) to either Talazoparib (once daily, 0.5 mg) + Enzalutamide (160 mg) group (N=402) or placebo group (N=403). The primary endpoint was radiographic progression-free survival, and secondary endpoints were overall survival, objective response rate, and PSA index.
The results showed that the median radiographic progression-free survival was: Talazoparib + Enzalutamide group: not reached / placebo group: 21.9 months. HRR-deficient patients in the Talazoparib + Enzalutamide group showed a 54% reduction in risk of radiographic progression or death compared to the placebo group. Patients without HRR deficiency in the Talazoparib + Enzalutamide group showed a 30% reduction in risk, while secondary endpoint data were not yet mature.
Regarding safety, the incidence of Grade 3–4 adverse events was: Talazoparib + Enzalutamide group 71.9% / placebo group 40.6%. Grade 3 or higher adverse events observed between groups were: Talazoparib + Enzalutamide group — anemia, neutropenia, and thrombocytopenia; placebo group — hypertension, anemia, and fatigue.
Based on the TALAPRO-2 trial results, Talazoparib + Enzalutamide as first-line treatment in metastatic castration-resistant prostate cancer patients improved radiographic progression-free survival regardless of HRR deficiency status.
Source: https://meetings.asco.org/abstracts-presentations/216877
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هل تفكر في تلقّي العلاج في اليابان؟ هل تحتاج إلى معلومات ومساعدة؟
نساعدك في تنظيم المعلومات اللازمة للسفر الطبي إلى اليابان، والتواصل مع المؤسسات الطبية اليابانية، وترتيب استشارة رأي ثانٍ.الاستشارة الأولى مجانية؛ سيساعدك المستشار على توضيح الخطوات التالية.
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