(Solid Tumors) Is Keytruda (Pembrolizumab) Effective as Neoadjuvant Therapy?
Medical Supporter — Мэдээллийн мэдэгдэл
Энэ нийтлэл нь олон улсын эмнэлгийн мэдээллийн эмхэтгэл бөгөөд эмнэлгийн зөвлөгөө биш; таны эмчийн оношлогоо, эмчилгээний төлөвлөгөөг орлохгүй. Энд буй мэдээлэл нь Японы томоохон эмнэлгийн байгууллагуудын нээлттэй эх сурвалжаас эмхэтгэсэн бөгөөд аливаа эмчилгээний тохиромж, үр дүн өвчтөн бүрээр өөр тул мэргэшсэн эмч тус бүрчлэн үнэлэх ёстой.
- February 3, 2023
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On January 9, 2023, Kaysia Ludford and colleagues from The University of Texas MD Anderson Cancer Center published Phase 2 clinical trial (NCT04082572) results in the Journal of Clinical Oncology, evaluating the efficacy and safety of Keytruda (pembrolizumab) as neoadjuvant therapy in patients with advanced metastatic solid tumors with MSI-High and dMMR status.
Trial Design
This was an open-label, independent-facility Phase 2 trial administering Keytruda (600 mg every 3 weeks, maximum 6 months) as neoadjuvant therapy to patients with advanced metastatic MSI-High/dMMR solid tumors. Following surgery, patients could continue treatment for up to one year based on individual choice. Primary endpoints: pathologic complete response (pCR) rate and safety. Secondary endpoint: organ preservation rate in patients not undergoing surgery.
Efficacy Results
Among 35 enrolled patients (27 colorectal cancer, 8 non-colorectal cancer):
- ORR (33 evaluable patients): 82%
- Pathologic complete response rate (17 surgical patients): 65%
Safety Profile
No new adverse events were identified; safety profile was consistent with known Keytruda data from other clinical trials.
Conclusions
Based on Phase 2 results, Kaysia Ludford et al. concluded that neoadjuvant Keytruda in MSI-High/dMMR advanced metastatic solid tumor patients demonstrated good tolerability and favorable pathologic complete response rates, offering patients an organ-preservation option.
Source: https://ascopubs.org/doi/abs/10.1200/JCO.22.01351?journalCode=jco
- Clinical trial drug
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Японд эмчлүүлэхээр төлөвлөж байна уу? Мэдээлэл, тусламж хэрэгтэй юу?
Бид Японд эмчлүүлэхэд шаардлагатай мэдээллийг эмхэтгэх, Японы эмнэлгийн байгууллагуудтай холбогдох, хоёр дахь саналын зөвлөгөө зохион байгуулахад тусална.Анхны зөвлөгөө үнэгүй; зөвлөх таны дараагийн алхмыг тодорхой болгоход тусална.
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