Keytruda and Chemotherapy in Advanced Endometrial Cancer
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Энэ нийтлэл нь олон улсын эмнэлгийн мэдээллийн эмхэтгэл бөгөөд эмнэлгийн зөвлөгөө биш; таны эмчийн оношлогоо, эмчилгээний төлөвлөгөөг орлохгүй. Энд буй мэдээлэл нь Японы томоохон эмнэлгийн байгууллагуудын нээлттэй эх сурвалжаас эмхэтгэсэн бөгөөд аливаа эмчилгээний тохиромж, үр дүн өвчтөн бүрээр өөр тул мэргэшсэн эмч тус бүрчлэн үнэлэх ёстой.
Keytruda and Chemotherapy in Advanced Endometrial Cancer
- August 2, 2023
- Reading time: 1 minute
On June 3, 2023, Dr. Ramez N. Eskander and colleagues from the University of California San Diego published the results of the Phase 3 NRG-GY018 trial in The New England Journal of Medicine. The study evaluated the addition of Keytruda (pembrolizumab) to standard first-line chemotherapy for patients with recurrent or advanced endometrial cancer.
Study Design: The NRG-GY018 trial enrolled 816 patients with Stage III, IVA, IVB, or recurrent endometrial cancer. Participants were randomized 1:1 into two groups:
- Keytruda Group: Keytruda plus chemotherapy (up to 6 cycles every three weeks), followed by Keytruda monotherapy as maintenance (up to 14 cycles every six weeks).
- Placebo Group: Standard chemotherapy plus placebo.
The primary endpoint was progression-free survival (PFS), stratified by mismatch-repair-deficient (dMMR) or mismatch-repair-proficient (pMMR) status.
Clinical Outcomes: The trial results showed significant improvements in PFS for the Keytruda group:
- dMMR Patients: The 12-month PFS rate was 74% in the Keytruda group compared to 38% in the placebo group.
- pMMR Patients: The median PFS was 13.1 months in the Keytruda group versus 8.7 months in the placebo group.
Conclusion: Based on the results of the NRG-GY018 trial, Dr. Ramez N. Eskander and the research team concluded that adding Keytruda to first-line chemotherapy significantly improves progression-free survival in patients with recurrent or advanced endometrial cancer.
Source: https://www.nejm.org/doi/full/10.1056/NEJMoa2302312
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